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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1615200
Species: Mus musculus
RGD Object: Gene
Symbol: Fasn
Name: fatty acid synthase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasndecreases expressionISOFASN (Homo sapiens)6480464CTDCisplatin results in decreased expression of FASN mRNAPMID:27594783
Fasnincreases expressionISOFasn (Rattus norvegicus)6480464CTDCisplatin results in increased expression of FASN proteinPMID:22023808
Fasnmultiple interactionsISOFASN (Homo sapiens)6480464CTD[4-methylene-2-octyl-5-oxofuran-3-carboxylic acid co-treated with Cisplatin] results in decreased expression of FASN protein; [4-methylene-2-octyl-5-oxofuran-3-carboxylic acid results in decreased activity of FASN protein] which results in increased susceptibility to Cisplatin; [Cisplatin co-treated with jinfukang] results in increased expression of FASN mRNAPMID:21442130 PMID:27392435
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