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GENE - TERM ANNOTATION REPORT

RGD ID: 1615176
Species: Mus musculus
RGD Object: Gene
Symbol: Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Acc ID: GO:0033173
Term: calcineurin-NFAT signaling cascade
Definition: Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
Definition Source(s): GOC:lm, GOC:mah, PMID:12975316, PMID:15928679
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfatc3involved_inIBAPANTHER:PTN0002833152290270GO_Central MGI:6201960 PMID:21873635

MGI:6201960 PMID:21873635
Nfatc3acts_upstream_of_or_withinIGIMGI:1071642290270MGI MGI:3821556 PMID:18676376

MGI:3821556 PMID:18676376
Nfatc3acts_upstream_of_or_withinIGIMGI:1071722290270MGI MGI:3830391 PMID:19179536

MGI:3830391 PMID:19179536
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