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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1614748
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of CYP2C54 mRNA

PMID:18467677, PMID:20813756, PMID:20936131, PMID:23811191
multiple interactionsEXP 6480464CTD[pirinixic acid co-treated with PPARA] results in decreased expression of CYP2C54 mRNA, PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP2C54 mRNA]

PMID:18467677, PMID:20813756
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.