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GENE - TERM ANNOTATION REPORT

RGD ID: 1614187
Species: Mus musculus
RGD Object: Gene
Symbol: Eny2
Name: ENY2 transcription and export complex 2 subunit
Acc ID: GO:0000124
Term: SAGA complex
Definition: A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
Definition Source(s): PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eny2 IBAPANTHER:PTN0002821532290270GO_Central (MGI:MGI:6201960, PMID:21873635)

MGI:MGI:6201960, PMID:21873635
Eny2 ISOUniProtKB:Q9NPA82290270MGI GO_REF:0000096, MGI:MGI:4834177
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.