Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1610909
Species: Mus musculus
RGD Object: Gene
Symbol: Neat1
Name: nuclear paraspeckle assembly transcript 1 (non-protein coding)
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Neat1affects response to substanceISONEAT1 (Homo sapiens)6480464CTDNEAT1 protein affects the susceptibility to CisplatinPMID:16217747 PMID:30291867
Neat1affects uptakeISONEAT1 (Homo sapiens)6480464CTDNEAT1 mRNA affects the uptake of CisplatinPMID:27270317
Neat1multiple interactionsISONEAT1 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of NEAT1 mRNA; [NEAT1 mRNA affects the uptake of Cisplatin] which affects the abundance of cisplatin-DNA adduct; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of ABCG2 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of and affects the phosphorylation of CTNNB1 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of and affects the phosphorylation of GSK3B protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of CD44 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of MMP2 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of MMP9 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of NANOG protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of POU5F1 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of PROM1 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of SOX2 proteinPMID:27270317 PMID:27392435 PMID:30291867
Go Back to source page   Continue to Ontology report