GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mir21a | decreases expression | ISO | MIR21 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of MIR21 mRNA | PMID:19264808 PMID:20302909 PMID:22403704 PMID:23052036 PMID:24758408 PMID:24877718 | Mir21a | increases expression | ISO | Mir21 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of MIR21 mRNA | PMID:26945725 | Mir21a | multiple interactions | ISO | MIR21 (Homo sapiens) | 6480464 | CTD | afimoxifene inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Cycloheximide inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; EGF protein inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein alternative form inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; MIR21 mRNA mutant form promotes the reaction [Estradiol results in increased expression of BCL2 protein]; MIR21 mRNA mutant form promotes the reaction [Estradiol results in increased expression of PDCD4 protein] | PMID:19264808 PMID:20302909 PMID:22403704 PMID:23052036 PMID:24758408 | |
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