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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1608349
Species: Mus musculus
RGD Object: Gene
Symbol: Mir21a
Name: microRNA 21a
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir21adecreases expressionISOMIR21 (Homo sapiens)6480464CTDEstradiol results in decreased expression of MIR21 mRNAPMID:19264808 PMID:20302909 PMID:22403704 PMID:23052036 PMID:24758408 PMID:24877718
Mir21aincreases expressionISOMir21 (Rattus norvegicus)6480464CTDEstradiol results in increased expression of MIR21 mRNAPMID:26945725
Mir21amultiple interactionsISOMIR21 (Homo sapiens)6480464CTDafimoxifene inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Cycloheximide inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; EGF protein inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein alternative form inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; ESR1 protein promotes the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; MIR21 mRNA mutant form promotes the reaction [Estradiol results in increased expression of BCL2 protein]; MIR21 mRNA mutant form promotes the reaction [Estradiol results in increased expression of PDCD4 protein]PMID:19264808 PMID:20302909 PMID:22403704 PMID:23052036 PMID:24758408
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