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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606587
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
Acc ID: CHEBI:6413
Term: letrozole
Definition: A triazole that has formula C17H11N5.
Chemical ID: MESH:C067431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP19A1decreases activityEXP 6480464CTDLetrozole results in decreased activity of CYP19A1 proteinPMID:15837728 PMID:15909811 PMID:16009161 PMID:16013988 PMID:16023854 PMID:16033851 PMID:16034487 PMID:16046582 PMID:16054421 PMID:16480277 PMID:17145897 PMID:21341743 PMID:24496634 PMID:29501854 PMID:30817981 PMID:32197950
CYP19A1increases activityEXP 6480464CTDletrozole results in increased activity of CYP19A1 proteinPMID:20087668
CYP19A1multiple interactionsEXP 6480464CTDLetrozole inhibits the reaction [[sodium arsenite results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol]; Letrozole inhibits the reaction [sodium arsenite results in increased activity of CYP19A1 protein]; Letrozole inhibits the reaction [sodium arsenite results in increased expression of CYP19A1 mRNA]PMID:24068038 PMID:32197950
CYP19A1decreases activityISOCyp19a1 (Mus musculus)6480464CTDletrozole results in decreased activity of CYP19A1 proteinPMID:15967659
CYP19A1decreases expressionISOCyp19a1 (Mus musculus)6480464CTDLetrozole results in decreased expression of CYP19A1 mRNAPMID:37030623
CYP19A1multiple interactionsISOCyp19a1 (Rattus norvegicus)6480464CTDletrozole binds to and results in decreased activity of CYP19A1 proteinPMID:24902786
CYP19A1multiple interactionsISOCyp19a1 (Mus musculus)6480464CTDdiacerein inhibits the reaction [Letrozole results in decreased expression of CYP19A1 mRNA]PMID:37030623
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