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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606587
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP19A1decreases activityEXP 6480464CTDnimesulide analog results in decreased activity of CYP19A1 protein; nimesulide results in decreased activity of CYP19A1; nimesulide results in decreased activity of CYP19A1 proteinPMID:15964185 PMID:17315855 PMID:20542113
CYP19A1decreases expressionEXP 6480464CTDnimesulide analog results in decreased expression of CYP19A1 mRNA; nimesulide results in decreased expression of CYP19A1 mRNAPMID:15964185 PMID:20542113
CYP19A1multiple interactionsEXP 6480464CTDnimesulide analog results in decreased activity of and results in decreased expression of CYP19A1PMID:17315855
CYP19A1decreases activityISOCyp19a1 (Rattus norvegicus)6480464CTDnimesulide results in decreased activity of CYP19A1 proteinPMID:23054057
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