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GENE - TERM ANNOTATION REPORT

RGD ID: 1606526
Species: Homo sapiens
RGD Object: Gene
Symbol: ISY1
Name: ISY1 splicing factor homolog
Acc ID: GO:0000974
Term: Prp19 complex
Definition: A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
Definition Source(s): GOC:krc, PMID:16540691, PMID:19239890
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ISY1part_ofIBAFB:FBgn0037550 or PANTHER:PTN000314659 or PomBase:SPBC32F12.05c or SGD:S000003811150520179GO_Central GO_REF:0000033
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