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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606037
Species: Homo sapiens
RGD Object: Gene
Symbol: DNMT3B
Name: DNA methyltransferase 3 beta
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DNMT3Bdecreases activityEXP 6480464CTDArsenic Trioxide results in decreased activity of DNMT3B proteinPMID:20596618
DNMT3Bdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of DNMT3B; Arsenic Trioxide results in decreased expression of DNMT3B mRNAPMID:12667347 PMID:12679007 PMID:17490527 PMID:20416177 PMID:20596618 PMID:21176356 PMID:29159499
DNMT3Bincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of DNMT3B mRNAPMID:25534098
DNMT3Bdecreases expressionISODnmt3b (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased expression of DNMT3B mRNAPMID:29223816
DNMT3Bdecreases expressionISODnmt3b (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of DNMT3B proteinPMID:19679824
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