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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605729
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGB1
Name: high mobility group box 1
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGB1increases expressionISOHmgb1 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of HMGB1 proteinPMID:25929181 PMID:28329851
HMGB1multiple interactionsISOHmgb1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]PMID:25929181 PMID:28329851
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