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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605705
Species: Homo sapiens
RGD Object: Gene
Symbol: GREB1
Name: growth regulating estrogen receptor binding 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GREB1affects expressionEXP 6480464CTDbisphenol A affects the expression of GREB1 mRNAPMID:30903817
GREB1increases expressionEXP 6480464CTDbisphenol A analog results in increased expression of GREB1 mRNA; bisphenol A results in increased expression of GREB1 mRNAPMID:16474171 PMID:22494775 PMID:23384675 PMID:27685785 PMID:28591870 PMID:28711546 PMID:29389661 PMID:31388671 PMID:32387340 PMID:33419253 PMID:35307500 PMID:36828454
GREB1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of GREB1 gene; bisphenol A promotes the reaction [ESR1 protein binds to GREB1 promoter]; bisphenol A promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]; ESR1 protein affects the reaction [bisphenol A results in increased expression of GREB1 mRNA]; ESR1 protein inhibits the reaction [bisphenol A analog results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of GREB1 mRNA]PMID:23019147 PMID:23384675 PMID:24856822 PMID:29389661 PMID:31601247
GREB1decreases expressionISOGreb1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of GREB1 mRNAPMID:25181051
GREB1decreases expressionISOGreb1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of GREB1 mRNAPMID:32156529
GREB1increases expressionISOGreb1 (Mus musculus)6480464CTDbisphenol A results in increased expression of GREB1 mRNAPMID:34585602
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