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GENE - TERM ANNOTATION REPORT

RGD ID: 1605400
Species: Homo sapiens
RGD Object: Gene
Symbol: TPPP
Name: tubulin polymerization promoting protein
Acc ID: GO:0005874
Term: microtubule
Definition: Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
Definition Source(s): ISBN:0879693568
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TPPPlocated_inIEAUniProtKB:Q7TQD2 or ensembl:ENSMUSP00000022057150520179Ensembl GO_REF:0000107
TPPPlocated_inIBAMGI:1920198 or PANTHER:PTN000309419 or UniProtKB:O94811150520179GO_Central GO_REF:0000033
TPPPlocated_inIEAPANTHER:PTHR12932:SF18150520179TreeGrafter GO_REF:0000118
TPPPlocated_inIDA 150520179UniProt PMID:18028908

PMID:18028908
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