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GENE - TERM ANNOTATION REPORT

RGD ID: 1605125
Species: Homo sapiens
RGD Object: Gene
Symbol: ERN1
Name: endoplasmic reticulum to nucleus signaling 1
Acc ID: GO:0070059
Term: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Definition Source(s): GOC:mah, GOC:mtg_apoptosis, PMID:18701708
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ERN1involved_inIEAUniProtKB:Q9EQY0 or ensembl:ENSMUSP00000001059150520179Ensembl GO_REF:0000107
ERN1involved_inIBAMGI:1349436 or MGI:1930134 or PANTHER:PTN000359335150520179GO_Central GO_REF:0000033
ERN1acts_upstream_of_or_withinISOErn1 (Mus musculus)9068941MGI PMID:11146108

PMID:11146108
ERN1involved_inIEAPANTHER:PTHR13954:SF17150520179TreeGrafter GO_REF:0000118
ERN1involved_inISSUniProtKB:Q9EQY0150520179UniProt GO_REF:0000024
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