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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605110
Species: Homo sapiens
RGD Object: Gene
Symbol: KEAP1
Name: kelch like ECH associated protein 1
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KEAP1increases expressionISOKeap1 (Rattus norvegicus)6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 mRNA; 9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 proteinPMID:24995432 PMID:33759307
KEAP1multiple interactionsISOKeap1 (Rattus norvegicus)6480464CTDbetulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein]PMID:24995432 PMID:33759307
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