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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605026
Species: Homo sapiens
RGD Object: Gene
Symbol: EIF2A
Name: eukaryotic translation initiation factor 2A
Acc ID: CHEBI:94807
Term: acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester
Definition: A carboxylic ester that has formula C12H9N3O5S.
Chemical ID: MESH:C041747
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF2Aincreases phosphorylationEXP 6480464CTDnitazoxanide results in increased phosphorylation of EIF2A proteinPMID:19664635
EIF2Amultiple interactionsEXP 6480464CTDIFNA2 protein promotes the reaction [nitazoxanide results in increased phosphorylation of EIF2A protein]; nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein]PMID:19664635
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