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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604618
Species: Homo sapiens
RGD Object: Gene
Symbol: CYCS
Name: cytochrome c, somatic
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYCSincreases expressionEXP 6480464CTDfulvestrant results in increased expression of CYCS mRNAPMID:20211987
CYCSmultiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Diethylstilbestrol affects the localization of CYCS protein]; fulvestrant inhibits the reaction [Estradiol affects the localization of CYCS protein]; fulvestrant inhibits the reaction [Genistein affects the localization of CYCS protein]; fulvestrant inhibits the reaction [Tamoxifen affects the localization of CYCS protein]PMID:16924424
CYCSmultiple interactionsISOCycs (Rattus norvegicus)6480464CTDfulvestrant inhibits the reaction [Estradiol results in increased expression of CYCS protein]PMID:15994367
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