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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603864
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP4A22
Name: cytochrome P450 family 4 subfamily A member 22
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP4A22multiple interactionsISOCyp4a1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Clofibrate] results in increased expression of CYP4A1 protein; [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4A22 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP4A22 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CYP4A1 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CYP4A1 mRNAPMID:10550479 PMID:18544905 PMID:18775883 PMID:22129741
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