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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603716
Species: Homo sapiens
RGD Object: Gene
Symbol: CCR2
Name: C-C motif chemokine receptor 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCR2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of CCR2 3' UTRPMID:27901495
CCR2decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of CCR2 5' UTRPMID:27901495
CCR2increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of CCR2 promoterPMID:27901495
CCR2decreases expressionISOCcr2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CCR2 mRNAPMID:21569818
CCR2increases expressionISOCcr2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CCR2 mRNAPMID:23735875
CCR2multiple interactionsISOCcr2 (Rattus norvegicus)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CCR2 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CCR2 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CCR2 mRNAPMID:18711122
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