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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603713
Species: Homo sapiens
RGD Object: Gene
Symbol: KNG1
Name: kininogen 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KNG1decreases expressionISOKng1 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of KNG1 mRNAPMID:31919559
KNG1increases expressionISOKng1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of KNG1 mRNAPMID:16644059
KNG1multiple interactionsISOKng1 (Rattus norvegicus)6480464CTDKNG1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; KNG1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; KNG1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]PMID:18054572
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