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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1599277
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Car14
Name: carbonic anhydrase 14
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car14affects methylationISOCA14 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CA14 exon; Benzo(a)pyrene affects the methylation of CA14 promoterPMID:27901495
Car14decreases expressionISOCA14 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CA14 mRNAPMID:26238291
Car14decreases expressionISOCar14 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CAR14 mRNAPMID:19770486 PMID:21569818 PMID:22228805 PMID:22610609
Car14increases expressionISOCar14 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CAR14 mRNAPMID:27195522
Car14multiple interactionsISOCar14 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CAR14 mRNAPMID:27858113
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