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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598663
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Elk1
Name: ETS transcription factor ELK1
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Elk1multiple interactionsISOELK1 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]PMID:12660819 PMID:18316600 PMID:21642427
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