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GENE - TERM ANNOTATION REPORT

RGD ID: 1596837
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbpl2
Name: TATA box binding protein-like 2
Acc ID: GO:0140223
Term: general transcription initiation factor activity
Definition: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
Definition Source(s): GOC:txnOH-2018
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
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