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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1596791
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hist4h4
Name: histone cluster 4, H4
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases acetylationISORGD:13467036480464CTDtrichostatin A results in increased acetylation of HIST4H4 protein

PMID:16009488, PMID:16740727, PMID:17330857, PMID:19503093
multiple interactionsISORGD:13467036480464CTD[[3-deazaneplanocin co-treated with trichostatin A] affects the acetylation of and affects the methylation of HIST4H4 protein] which affects the expression of DACT3, [trichostatin A co-treated with Dexamethasone] inhibits the reaction [IL1B protein promotes the reaction [HIST4H4 protein modified form binds to CSF2 promoter]], trichostatin A promotes the reaction [HIST4H4 protein modified form binds to CCNA1 promoter], trichostatin A promotes the reaction [HIST4H4 protein modified form binds to PTEN promoter]

PMID:12070353, PMID:17330857, PMID:17698632, PMID:18538736
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.