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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1596428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itga2b
Name: integrin subunit alpha 2b
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itga2bdecreases expressionISOITGA2B (Homo sapiens)6480464CTDAspirin results in decreased expression of ITGA2B proteinPMID:15381054
Itga2bmultiple interactionsISOITGA2B (Homo sapiens)6480464CTDAspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]]PMID:15140583 PMID:15381054 PMID:18413191
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