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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595860
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ezh2affects expressionEXP 6480464CTDbisphenol A affects the expression of EZH2 mRNAPMID:32145629
Ezh2increases expressionEXP 6480464CTDbisphenol A results in increased expression of EZH2 mRNA; bisphenol A results in increased expression of EZH2 proteinPMID:25088689 PMID:26898831 PMID:27697584 PMID:30816183
Ezh2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of EZH2 mRNA; [bisphenol A co-treated with Estradiol] results in increased expression of EZH2 proteinPMID:25088689
Ezh2affects expressionISOEZH2 (Homo sapiens)6480464CTDbisphenol A affects the expression of EZH2 mRNAPMID:28765096
Ezh2decreases expressionISOEZH2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of EZH2 mRNAPMID:29275510
Ezh2decreases expressionISOEzh2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of EZH2 mRNAPMID:30015891 PMID:36508816
Ezh2increases acetylationISOEZH2 (Homo sapiens)6480464CTDbisphenol A results in increased acetylation of EZH2 promoterPMID:25088689
Ezh2increases expressionISOEZH2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of EZH2 mRNA; bisphenol A results in increased expression of EZH2 proteinPMID:21761357 PMID:25088689 PMID:32030086
Ezh2increases expressionISOEzh2 (Mus musculus)6480464CTDbisphenol A results in increased expression of EZH2 proteinPMID:21761357
Ezh2increases methylationISOEZH2 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of EZH2 promoterPMID:25088689
Ezh2increases methylationISOEzh2 (Mus musculus)6480464CTDbisphenol A results in increased methylation of EZH2 gene; bisphenol A results in increased methylation of EZH2 promoterPMID:30841672 PMID:36508816
Ezh2multiple interactionsISOEZH2 (Homo sapiens)6480464CTDbisphenol A promotes the reaction [CREBBP protein binds to EZH2 promoter]; bisphenol A promotes the reaction [EP300 protein binds to EZH2 promoter]; bisphenol A promotes the reaction [ESR1 protein binds to EZH2 promoter]; bisphenol A promotes the reaction [ESR2 protein binds to EZH2 promoter]; bisphenol A promotes the reaction [KMT2C protein binds to EZH2 promoter]; bisphenol A promotes the reaction [KMT2D protein binds to EZH2 promoter]; KMT2C mutant form inhibits the reaction [bisphenol A results in increased expression of EZH2 mRNA]; KMT2D mutant form inhibits the reaction [bisphenol A promotes the reaction [CREBBP protein binds to EZH2 promoter]]; KMT2D mutant form inhibits the reaction [bisphenol A promotes the reaction [EP300 protein binds to EZH2 promoter]]; KMT2D mutant form inhibits the reaction [bisphenol A results in increased acetylation of EZH2 promoter]; KMT2D mutant form inhibits the reaction [bisphenol A results in increased expression of EZH2 mRNA]; KMT2D mutant form inhibits the reaction [bisphenol A results in increased methylation of EZH2 promoter]PMID:25088689
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