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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595785
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rorc
Name: RAR-related orphan receptor C
Acc ID: CHEBI:36704
Term: imiquimod
Definition: An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
Chemical ID: MESH:C056493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rorcincreases expressionISORorc (Mus musculus)6480464CTDimiquimod results in increased expression of RORC mRNA; imiquimod results in increased expression of RORC proteinPMID:26149470
Rorcmultiple interactionsISORorc (Mus musculus)6480464CTD(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]; (+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein]PMID:26149470
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