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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593809
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pcp4l1
Name: Purkinje cell protein 4-like 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pcp4l1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of PCP4L1 mRNAPMID:31511937
Pcp4l1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of PCP4L1 mRNAPMID:21215274
Pcp4l1affects expressionISOPcp4l1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of PCP4L1 mRNAPMID:20702594 PMID:24680724 PMID:26377647 PMID:28922406
Pcp4l1decreases expressionISOPcp4l1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of PCP4L1 mRNAPMID:33956508
Pcp4l1increases expressionISOPcp4l1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of PCP4L1 mRNAPMID:19770486 PMID:21889950 PMID:25270620 PMID:25975270 PMID:26290441 PMID:31511937
Pcp4l1multiple interactionsISOPcp4l1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PCP4L1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of PCP4L1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PCP4L1 gene]PMID:16214954 PMID:21762485 PMID:25975270
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