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GENE - TERM ANNOTATION REPORT

RGD ID: 1593294
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp1b
Name: NLR family, pyrin domain containing 1B
Acc ID: GO:0050700
Term: CARD domain binding
Definition: Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.
Definition Source(s): PMID:12054670
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
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