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GENE - TERM ANNOTATION REPORT

RGD ID: 1593252
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tead2
Name: TEA domain transcription factor 2
Acc ID: GO:0035329
Term: hippo signaling
Definition: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
Definition Source(s): PMID:17318211, PMID:18328423, PMID:36347846
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tead2involved_inISOTEAD2 (Homo sapiens)1624291RGD PMID:18579750 PMID:19324877

PMID:18579750 PMID:19324877
Tead2involved_inIBAMGI:101876 or PANTHER:PTN000931330 or UniProtKB:P28347 or UniProtKB:Q15561 or UniProtKB:Q15562 or UniProtKB:Q995941600115GO_CentralGO_REF:0000033

GO_REF:0000033
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