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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpoincreases activityEXP 6480464CTDCisplatin results in increased activity of MPO proteinPMID:20676799 PMID:24291008 PMID:25184746
Mpomultiple interactionsEXP 6480464CTDacetovanillone inhibits the reaction [Cisplatin results in increased activity of MPO protein]; fisetin inhibits the reaction [Cisplatin results in increased activity of MPO protein]; pycnogenols inhibits the reaction [Cisplatin results in increased activity of MPO protein]PMID:20676799 PMID:24291008 PMID:25184746
Mpoaffects response to substanceISOMPO (Homo sapiens)6480464CTDMPO gene polymorphism affects the susceptibility to CisplatinPMID:16785472
Mpodecreases expressionISOMPO (Homo sapiens)6480464CTDCisplatin results in decreased expression of MPO mRNAPMID:27594783
Mpoincreases activityISOMpo (Mus musculus)6480464CTDCisplatin results in increased activity of MPO proteinPMID:26546572 PMID:31874189
Mpoincreases expressionISOMpo (Mus musculus)6480464CTDCisplatin results in increased expression of MPO proteinPMID:31153982
Mpomultiple interactionsISOMpo (Mus musculus)6480464CTD4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased activity of MPO protein]; hesperetin inhibits the reaction [Cisplatin results in increased expression of MPO protein]PMID:26546572 PMID:31153982
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