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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tyr
Name: tyrosinase
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tyrmultiple interactionsISOTyr (Mus musculus)6480464CTD[Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of TYR proteinPMID:28849034
Tyrmultiple interactionsISOTYR (Homo sapiens)6480464CTD[Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR proteinPMID:28849034
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