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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rgs16
Name: regulator of G-protein signaling 16
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rgs16decreases expressionISORgs16 (Mus musculus)6480464CTDDexamethasone results in decreased expression of RGS16 mRNAPMID:27645313
Rgs16increases expressionISORgs16 (Mus musculus)6480464CTDDexamethasone results in increased expression of RGS16 mRNAPMID:22733784
Rgs16multiple interactionsISORgs16 (Mus musculus)6480464CTDapicidin inhibits the reaction [Dexamethasone results in decreased expression of RGS16 mRNA]; KDM1A protein affects the reaction [Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of RGS16 mRNA]]; Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of RGS16 mRNA]PMID:27645313
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