GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnfaip3 | increases expression | ISO | TNFAIP3 (Homo sapiens) | 151347604 | RGD | Lipopolysaccharide increases expression of TNFAIP3 protein in liver | | Tnfaip3 | increases expression | ISO | Tnfaip3 (Mus musculus) | 151347604 | RGD | Lipopolysaccharide increases expression of TNFAIP3 protein in mammary gland | | Tnfaip3 | increases activity | ISO | TNFAIP3 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased activity of TNFAIP3 protein | PMID:15451058 | Tnfaip3 | increases expression | ISO | TNFAIP3 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of TNFAIP3 mRNA; Lipopolysaccharides results in increased expression of TNFAIP3 protein | PMID:15451058 PMID:23724058 PMID:34416243 PMID:35811015 | Tnfaip3 | increases expression | ISO | Tnfaip3 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of TNFAIP3 mRNA; Lipopolysaccharides results in increased expression of TNFAIP3 protein | PMID:20423518 PMID:24453940 PMID:25890327 PMID:26582142 | Tnfaip3 | increases response to substance | ISO | Tnfaip3 (Mus musculus) | 6480464 | CTD | TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides | PMID:24453940 | Tnfaip3 | multiple interactions | ISO | TNFAIP3 (Homo sapiens) | 6480464 | CTD | [Lipopolysaccharides co-treated with TNFSF11 protein] results in increased expression of TNFAIP3 protein; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of TNFAIP3 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of TNFAIP3 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [RNF31 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [RNF31 protein inhibits the reaction [TNFAIP3 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [RNF31 protein inhibits the reaction [TNFAIP3 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]; RNF31 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 protein]; RNF31 protein inhibits the reaction [TNFAIP3 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; RNF31 protein inhibits the reaction [TNFAIP3 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; TNFAIP3 protein affects the reaction [RNF31 protein affects the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; TNFAIP3 protein affects the reaction [RNF31 protein affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; TNFAIP3 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; TNFAIP3 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; TNFAIP3 protein promotes the reaction [Lipopolysaccharides results in increased degradation of TRAF6 protein]; Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased activity of TNFAIP3 protein]; Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA] | PMID:15451058 PMID:21127049 PMID:23724058 PMID:34416243 PMID:35811015 | Tnfaip3 | multiple interactions | ISO | Tnfaip3 (Mus musculus) | 6480464 | CTD | [Lipopolysaccharides co-treated with Galactose] results in increased expression of TNFAIP3 protein; [Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of TNFAIP3 mRNA; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2 mRNA; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 mRNA; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 protein; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL13 protein; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL6 protein; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of TNF protein; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2 mRNA]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 mRNA]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 protein]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL13 protein]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL6 protein]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of TNF protein]; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNFAIP3 protein]; TNFAIP3 protein affects the reaction [Lipopolysaccharides results in increased degradation of and results in increased phosphorylation of NFKBIA protein] | PMID:20423518 PMID:24453940 PMID:32035082 PMID:34416243 | | ||||||||||||||||||||||
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