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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1588560
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbc1d16
Name: TBC1 domain family, member 16
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbc1d16affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of TBC1D16 mRNAPMID:22298810
Tbc1d16affects expressionISOTbc1d16 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TBC1D16 mRNAPMID:24680724 PMID:26377647
Tbc1d16increases expressionISOTbc1d16 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TBC1D16 mRNAPMID:19770486 PMID:19933214 PMID:25975270 PMID:26290441 PMID:33956508
Tbc1d16multiple interactionsISOTbc1d16 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TBC1D16 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TBC1D16 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TBC1D16 gene]PMID:16214954 PMID:21762485 PMID:25975270
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