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GENE - TERM ANNOTATION REPORT

RGD ID: 1588543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brcc3
Name: BRCA1/BRCA2-containing complex subunit 3
Acc ID: GO:0070531
Term: BRCA1-A complex
Definition: A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
Definition Source(s): GOC:mah, PMID:19261749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brcc3part_ofISOBRCC3 (Homo sapiens)1624291RGD PMID:17525341 PMID:19202061 PMID:19261746 PMID:19261748 PMID:19261749

PMID:17525341 PMID:19202061 PMID:19261746 PMID:19261748 PMID:19261749
Brcc3part_ofIBAPANTHER:PTN000045567 or UniProtKB:P467361600115GO_CentralGO_REF:0000033

GO_REF:0000033
Brcc3part_ofISSUniProtKB:P467361600115UniProtGO_REF:0000024

GO_REF:0000024
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