GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Thbs1 | increases expression | ISO | THBS1 (Homo sapiens) | 6480464 | CTD | sulindac sulfide results in increased expression of THBS1 mRNA; sulindac sulfide results in increased expression of THBS1 protein | PMID:16227405 PMID:18261746 | Thbs1 | multiple interactions | ISO | THBS1 (Homo sapiens) | 6480464 | CTD | [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein] | PMID:16227405 PMID:18261746 | | ||||||||||||||||||||||
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