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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa6l-ps1
Name: heat shock protein family A (Hsp70) member 6 like, pseudogene 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa6l-ps1increases expressionISOHSPA6 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of HSPA6 mRNA; Arsenic Trioxide results in increased expression of HSPA6 proteinPMID:15978632 PMID:19364129 PMID:19417148 PMID:24356939
Hspa6l-ps1multiple interactionsISOHSPA6 (Homo sapiens)6480464CTDMAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSPA6 mRNA]; MAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSPA6 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA6 mRNA]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA6 protein]PMID:15978632
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