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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586165
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kmt2a
Name: lysine methyltransferase 2A
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kmt2aincreases expressionISOKMT2A (Homo sapiens)6480464CTDdeoxynivalenol results in increased expression of KMT2A mRNAPMID:19438726
Kmt2amultiple interactionsISOKMT2A (Homo sapiens)6480464CTDAG 1879 inhibits the reaction [deoxynivalenol results in increased expression of KMT2A mRNA]; deoxynivalenol promotes the reaction [SP1 protein binds to KMT2A promoter]; SP1 protein promotes the reaction [deoxynivalenol results in increased expression of KMT2A mRNA]PMID:19438726
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