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GENE - TERM ANNOTATION REPORT

RGD ID: 1585921
Species: Rattus norvegicus
RGD Object: Gene
Symbol: LRRTM1
Name: leucine rich repeat transmembrane neuronal 1
Acc ID: GO:0031623
Term: receptor internalization
Definition: A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
Definition Source(s): GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LRRTM1acts_upstream_ofISOLrrtm1 (Mus musculus)1624291RGDMGI:2389174 PMID:23931994

PMID:23931994
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