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GENE - TERM ANNOTATION REPORT

RGD ID: 1585896
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Med12
Name: mediator complex subunit 12
Acc ID: GO:0060071
Term: Wnt signaling pathway, planar cell polarity pathway
Definition: A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton.
Definition Source(s): PMID:11532397, PMID:25349257, PMID:28293032, PMID:37804416
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Med12acts_upstream_of_or_withinISOMed12 (Mus musculus)1624291RGDMGI:4839486 PMID:20630950

PMID:20630950
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