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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583765
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp3
Name: Sp3 transcription factor
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp3decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of SP3 proteinPMID:25068794
Sp3multiple interactionsEXP 6480464CTDHDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]PMID:25068794
Sp3decreases expressionISOSP3 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of SP3 proteinPMID:25068794
Sp3multiple interactionsISOSP3 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]; Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]; Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]; Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein; HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein]; MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]; MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]]; MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein]; MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]PMID:25068794
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