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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583689
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a5
Name: UDP glucuronosyltransferase family 1 member A5
Acc ID: CHEBI:45951
Term: trifluoperazine
Definition: A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Chemical ID: MESH:D014268
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:13435196480464CTDTrifluoperazine results in increased activity of UGT1A4 protein

PMID:26875642
increases glucuronidationISORGD:13435196480464CTDUGT1A4 protein results in increased glucuronidation of Trifluoperazine

PMID:15135306, PMID:15475412, PMID:25393417, PMID:25448279
multiple interactionsISORGD:13435196480464CTDFinasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine], hecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine], licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein], Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]

PMID:15475412, PMID:25448279, PMID:26875642
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.