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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDPaclitaxel results in increased expression of H2AX protein; Paclitaxel results in increased expression of H2AX protein modified formPMID:18451153 PMID:22302033 PMID:34272796
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTDPaclitaxel promotes the reaction [norcantharidin results in increased expression of H2AX protein modified form]; palbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AX protein]PMID:22302033 PMID:34272796
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