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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:34238
Term: 2,4-dibromophenol
Definition: A bromophenol that is phenol in which the hydrogens at positions 2 and 4 have been replaced by bromines.
Chemical ID: MESH:C013930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionISOH2ax (Mus musculus)6480464CTD2,4-dibromophenol metabolite results in increased expression of H2AX protein modified formPMID:33961949
H2axmultiple interactionsISOH2ax (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]PMID:33961949
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