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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axmultiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [bisphenol A results in increased expression of H2AX protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein]PMID:23788033
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein modified form]; Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form]; Fulvestrant inhibits the reaction [propylparaben results in increased expression of H2AX protein modified form]PMID:31939680
H2axmultiple interactionsISOH2ax (Mus musculus)6480464CTDFulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in decreased expression of H2AX protein]; Fulvestrant inhibits the reaction [Mestranol results in decreased expression of H2AX protein]PMID:36098747
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