GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | H2ax | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of H2AX protein modified form | PMID:34283317 | H2ax | increases expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene metabolite results in increased expression of H2AX protein; Benzo(a)pyrene results in increased expression of H2AX protein; Benzo(a)pyrene results in increased expression of H2AX protein modified form | PMID:21873372 PMID:26657896 PMID:31051210 PMID:31733235 PMID:32087850 PMID:33249052 PMID:35690182 PMID:37390851 PMID:37515497 | H2ax | increases expression | ISO | H2ax (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene metabolite results in increased expression of H2AX protein modified form | PMID:32553695 | H2ax | increases methylation | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of H2AX promoter | PMID:27901495 | H2ax | increases phosphorylation | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased phosphorylation of H2AX protein | PMID:20888899 PMID:22389207 PMID:26148434 PMID:28882572 PMID:29126329 PMID:33393179 PMID:34510228 | H2ax | increases phosphorylation | ISO | H2ax (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased phosphorylation of H2AX protein | PMID:19770486 PMID:33393179 | H2ax | multiple interactions | ISO | H2AX (Homo sapiens) | 6480464 | CTD | 2,4,3',5'-tetramethoxystilbene inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]; [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AX protein; [fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein; [pyrene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein; [pyrene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]; alvocidib inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]; ARNT protein affects the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]; Benzo(a)pyrene results in increased expression of and results in increased phosphorylation of H2AX protein; Butyric Acid promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased phosphorylation of H2AX protein]; Caffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AX protein]; CYP1A1 protein affects the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]; PCB 180 metabolite promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]; THZ1 compound inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]; TP53 protein affects the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]; wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] | PMID:20888899 PMID:21882252 PMID:26148434 PMID:28882572 PMID:31733235 PMID:33249052 PMID:33393179 PMID:36399157 PMID:37515497 | H2ax | multiple interactions | ISO | H2ax (Mus musculus) | 6480464 | CTD | pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] | PMID:33393179 | | ||||||||||||||||||||||
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