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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:16509
Term: 1,4-benzoquinone
Definition: The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
Chemical ID: MESH:C004532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionISOH2ax (Mus musculus)6480464CTDquinone analog results in increased expression of H2AX protein modified formPMID:33961949
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDquinone results in increased phosphorylation of H2AX proteinPMID:18835433
H2axincreases phosphorylationISOH2ax (Mus musculus)6480464CTDquinone results in increased phosphorylation of H2AX proteinPMID:31340051
H2axmultiple interactionsISOH2ax (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]PMID:33961949
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