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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566041
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tuba8
Name: tubulin, alpha 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tuba8affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of TUBA8 mRNAPMID:22298810
Tuba8increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of TUBA8 mRNAPMID:33387578
Tuba8affects expressionISOTuba8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TUBA8 mRNAPMID:21570461 PMID:26377647
Tuba8increases expressionISOTuba8 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TUBA8 mRNAPMID:16214954 PMID:19770486 PMID:25975270 PMID:26290441
Tuba8multiple interactionsISOTuba8 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TUBA8 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUBA8 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TUBA8 mRNAPMID:16214954 PMID:17942748 PMID:25975270
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