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GENE - TERM ANNOTATION REPORT

RGD ID: 1564440
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sohlh1
Name: spermatogenesis and oogenesis specific basic helix-loop-helix 1
Acc ID: DOID:1924
Term: hypogonadism
Definition: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
Definition Source(s): MESH:D007006, http://en.wikipedia.org/wiki/Hypogonadism
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:16051848554872ClinVarClinVar Annotator: match by term: Nonsyndromic hypergonadotropic hypogonadism

PMID:17301727, PMID:25741868, PMID:25774885
 ISORGD:16051848554872ClinVarClinVar Annotator: match by term: Nonsyndromic hypergonadotropic hypogonadism

PMID:25774885
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.